Cinnamic acids and derivatives
TARGETMOL CHEMICALS INC Tyrphostin AG 528 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50 4.9 uM) and ErbB2 (IC50 2.1 uM). Purity 99.74%
Medchemexpress LLC 3-Methylcinnamic acid | MFCD00016844 | >99.7% | C10H10O2 | 100 G
3-Methylcinnamic acid is a solid, white to off-white chemical compound. It serves as a drug intermediate for the synthesis of various active compounds and is intended for research use only.
- Solid appearance
- White to off-white color
- Molecular weight of 162.19
- For research use only
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 10 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor, intended for research use only.
- Inhibits EGFR phosphorylation.
- Detailed solubility information for in vitro and in vivo applications is available.
- Comprehensive documentation including Data Sheet, COA, SDS, HNMR, LCMS, and Handling Instructions.
- Target: EGFR.
- Pathway: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK.
Selleck Chemical LLC Tyrphostin AG 1296
Tyrphostin AG 1296 is an inhibitor of PDGFR with IC50 of 0 3-0 5 M no activity to EGFR Tyrphostin AG1296 inhibits FGFR and c-Kit with IC50 of 12 3 M and 1 8 M in Swiss 3T3 cells Tyrphostin AG1296 induces dramatic apoptosis in A375R cells
Medchemexpress LLC m-Coumaric acid (Standard) | 588-30-7 | 99.91% | 164.16 | 25 MG
m-Coumaric acid (Standard) is the analytical standard of m-Coumaric acid, intended for research and analytical applications. It is a polyphenol metabolite from caffeic acid, formed by gut microflora, with its amount in human biofluids being diet-dependent. m-Coumaric acid is also a BBB-penetrant metabolite of chlorogenic acid.
- Stimulates the cerebral nerves in vitro.
- Can evoke neurite outgrowth in hippocampal neuronal cells.
- Can promote neuronal differentiation.
- Increases spontaneous locomotor activity in mice by acting on the central nervous system.
- Inhibits the oxidation of L-dopa by epidermis tyrosinase.
- Attenuates non-catalytic protein glycosylation in retinas of diabetic rats.
Medchemexpress LLC p-Coumaric Acid Ethyl Ester | 7362-39-2 | 25 MG
p-Coumaric Acid Ethyl Ester is a non-competitive, reversible inhibitor of tyrosinase, utilized in the development of medicines, cosmetics, and fruit preservation products. It boasts a purity of 99.19% and a molecular weight of 192.21, presenting as a light yellow to light brown solid. This compound also exhibits anti-platelet activity.
- Non-competitive, reversible tyrosinase inhibitor
- IC50 of 4.89 μg/mL and Ki of 1.83 μg/mL against tyrosinase
- Quenches intrinsic fluorescence of the enzyme
- Alters L-tyrosine binding affinity through conformational changes in tyrosinase
- Does not bind to the enzyme's copper ion
- Shows anti-platelet activity in rabbit platelet-rich plasma (IC50 = 130.4 μM)
- Soluble in DMSO at 100 mg/mL
![Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211898.png-250.jpg)
Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML
(+)-Tyrphostin B44 is the (+) enantiomer of Tyrphostin AG-835, a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) used in biochemical and cellular research. It is provided as a concentrated solution in DMSO for in vitro assays and is documented with supporting datasheet, certificate of analysis, and safety data information.
- Provides EGFR inhibitory activity useful for signaling and cancer research.
- Supplied as a 10 mM solution in DMSO for ready-to-use preparations.
- High purity suitable for research applications (≈97%).
- Characterized molecular properties for accurate dosing in assays.
- Documentation available to support safe handling and experimental reproducibility.
Medchemexpress LLC 4-(3-Fluorobenzyloxy)benzaldehyde | 66742-57-2 | 99.8% | C14H11FO2 | 100 G
4-(3-Fluorobenzyloxy)benzaldehyde is a chemical compound that serves as a drug intermediate. It is used in the synthesis of various active compounds for research purposes.
- Solid appearance
- Functions as a drug intermediate
- Suitable for the synthesis of active compounds
- For research use only
- Shipped at room temperature in continental US
- Store at 4°C under nitrogen
- When in solvent, store at -80°C for 6 months or -20°C for 1 month under nitrogen
Medchemexpress LLC 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 99.9% | 238.24 | 25 G
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of *Polygala tenuifolia WILLD*. It has an anti-stress effect and can prolong sleeping time in animals. This compound increases the expression of GAD65 and the γ-subunit of the GABAA receptor, but it does not affect the amounts of α- and β-subunits.
- Anti-stress effect
- Prolongs sleeping time in animals
- Increases expression of GAD65 and γ-subunit of GABAA receptor
- Exhibits sedative effect in rats
- Significantly decreases locomotor activity in mice
- Available in solid form, white to off-white color
Chem-Impex International, Inc. trans-Ferulic acid | 1135-24-6 | MFCD00004400 | 1KG
trans-Ferulic acid, 1135-24-6, MFCD00004400, 1KG
Medchemexpress LLC Tyrphostin AG 528 | 133550-49-9 | MFCD01076474 | 98.0% | 306.32 g·mol^-1 | C18H14N2O3 | 25 MG
Tyrphostin AG 528 is a small-molecule protein tyrosine kinase inhibitor used as a research reagent to probe EGFR and ErbB2 (HER2) signaling pathways. It is supplied as a high-purity solid for biochemical and cellular studies.
- Inhibits EGFR and ErbB2 with reported IC50s of 4.9 μM and 2.1 μM.
- High purity (98.0%) suitable for laboratory research.
- Supplied as a solid, light yellow to yellow in color.
- Molecular weight 306.32 g·mol⁻¹; formula C18H14N2O3.
- Available in small research quantities, including 25 mg packaging.